ImmunologybioRxiv
Ruxolitinib partially reverses functional NK cell deficiency in patients with STAT1 gain-of-function mutations
A. Vargas Hernandez, E. M. Mace, O. Zimmerman…·L. R. Forbes
This study shows that ruxolitinib partially restores NK cell function in STAT1 GOF patients by reducing STAT1 phosphorylation and improving cytotoxic activity.
DOI 10.1016/j.jaci.2017.08.040