E. M. Mace

cellPLATO: an unsupervised method for identifying cell behaviour in heterogeneous cell trajectory data

cellPLATO identifies cell behaviour in trajectory data by clustering morphology and motility metrics, revealing IL-15's role in increasing NK cell migration plasticity.

Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency

This study shows that allelic bias in GINS4 variants contributes to variable clinical and cellular phenotypes in NK cell deficiency.

Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry & high-resolution microscopy

This study maps human natural killer cell development in pediatric tonsil using imaging mass cytometry and high-resolution microscopy, revealing stage-specific localization and interactions.

The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity

The paper identifies the CD58:CD2 axis as co-regulated with PD-L1 via CMTM6 and shows its role in anti-tumor immunity, proposing therapeutic strategies to enhance immunotherapy.

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer

This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.

CD56 at the human NK cell lytic immunological synapse

This study investigates CD56's role in NK cell cytotoxicity by examining its localization at the immunological synapse and its impact on lytic granule exocytosis.

Fibroblast activation protein regulates natural killer cell migration, extravasation and tumor infiltration

This study shows that fibroblast activation protein (FAP) is expressed by human NK cells and promotes their migration, extravasation, and tumor infiltration, suggesting FAP as a target to enhance NK cell-based therapies.

Differential integrin adhesome expression defines human natural killer cell residency and developmental stage

This study identifies differences in integrin adhesome expression in human NK cells based on tissue location and developmental stage, linking these differences to cortical actin homeostasis.

Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Transcriptional and Biochemical Function

This study identifies a JAK1 mutation causing autoinflammation and shows its unique transcriptional and functional effects through single-cell analysis and clinical treatment.

Generation of cell-free matrices that support human NK cell migration and differentiation

This study generates cell-derived matrices that support human NK cell migration and differentiation, showing they can replace intact stromal cells for in vitro NK cell development.

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes

This study shows helminth infections cause long-term DNA methylation and immune changes that impair TB-specific immune responses.

Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors

The paper tracks NK cell progenitors over weeks using phase-contrast microscopy, showing increased motility and heterogeneous migratory behaviors during differentiation.

Ruxolitinib partially reverses functional NK cell deficiency in patients with STAT1 gain-of-function mutations

This study shows that ruxolitinib partially restores NK cell function in STAT1 GOF patients by reducing STAT1 phosphorylation and improving cytotoxic activity.