Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions
J. H. Kim, K. J. Megquier, R. Thomas, A. L. Sarver, J. M. Song, Y. T. Kim, A. J. Schulte, N. Cheng, M. A. Linden, P. Murugan, L. Oseth, C. L. Foster, I. Elvers, R. Swofford, J. Turner-Maier, , J. F. Modiano
This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.
bioRxiv · Aug 11, 2020Cancer Biology