N. Cheng

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Exploring Behavioral and Neural Dynamics of Social Interactions during the Juvenile Stage in a Mouse Model of Fragile X Syndrome

This study examines social behavior and cortical activity in juvenile Fmr1 knockout and heterozygous mice, revealing sex- and genotype-dependent differences in social interactions and oscillatory brain activity.

Improving vocal communication with a ketogenic diet in a mouse model of autism

This study shows that a ketogenic diet improves vocal communication in BTBR mice, a model of autism, by enhancing ultrasonic vocalization parameters in both juvenile and adult mice.

Longevity Bottlenecks

This paper surveys experts in longevity to identify key bottlenecks and solutions, finding that data sharing and regulatory clarity are critical for advancing aging research.

Clathrin Light Chains are essential in negative regulation of cell death and immunity in Arabidopsis through interacting with autophagy pathway

This study shows that clathrin light chains in Arabidopsis interact with autophagy proteins, impairing autophagy and leading to accelerated senescence and immune activation.

Markerless mouse tracking for social experiments

This paper introduces a markerless video tracking tool for two socially interacting mice, showing improved accuracy over deep learning alone in tracking and analyzing social behaviors.

Hemangiosarcoma Cells Promote Conserved Host-Derived Hematopoietic Expansion

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

High-resolution positron emission microscopy of patient-derived tumor organoids

This paper develops a high-resolution microscopy method to image FDG in tumor organoids, mirroring clinical PET scans and predicting treatment response.