J. F. Modiano

This study evaluates neoadjuvant oncolytic virus therapy in dogs with osteosarcoma, finding it safe and associated with increased long-term survivorship and immune gene expression.

The paper develops a gene signature using exosomal RNA from canine osteosarcoma xenografts and machine learning to detect residual disease in dogs, showing improved remission outcomes in validation samples.

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

This study identifies DNA methylation patterns in human and canine osteosarcoma samples that correlate with conserved transcriptional programs and tumor states, not cell composition.

This study shows ADAM17 mediates L-selectin shedding in canine neutrophils, which could be a therapeutic target for inflammation.

The paper analyzes blood and tissue biomarkers in dogs with osteosarcoma treated with radiation and NK cell therapy, finding correlations between immune markers and survival.