Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response
P. Zhang, I. Kitchen-Smith, L. Xiong, G. Stracquadanio, K. Brown, P. Richter, M. Wallace, E. Bond, N. Sahgal, S. Moore, S. Nornes, S. De Val, M. Surakhy, D. Sims, X. Wang, , G. Bond
The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.
bioRxiv · Nov 9, 2019Cancer Biology