M. Wallace

'Disease-smart' assisted migration can enhance population fitness and increase resistance to pathogens via immune priming

The paper shows that adding immune-primed migrants to small inbred populations improves survival against pathogens, while non-primed migrants only enhance reproduction.

Quantifying acyl-chain diversity in isobaric compound lipids containing monomethyl branched-chain fatty acids

The paper develops a method to quantify acyl-chain diversity in isobaric compound lipids using UHPLC-MS and validates it with metabolically engineered adipocytes.

Sex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier

This study investigates the role of the mitochondrial pyruvate carrier (MPC) in adipose glucose partitioning, finding sex-dependent effects on triglyceride synthesis and metabolic adaptation in mice.

Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain

This study measures fatty acid composition in human milk and finds that monomethyl branched-chain fatty acids (mmBCFAs) vary with gestational weight gain, with lower levels in women with excess weight gain.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

The Lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

This study shows that the Lamin A/C Ig-fold undergoes cell density-dependent conformational changes that affect antibody binding, without altering protein levels or nuclear mechanics.

A widespread methylotroph acyl-homoserine lactone synthase produces an atypical quorum sensing signal

The paper identifies an atypical quorum sensing signal produced by pink pigmented facultative methylotrophs using inverse stable isotopic labeling and shows it activates a LuxR-family transcription factor.

Increasing Muscle Hypertrophy with a Natural Product Designed to Inhibit SIRT1

This study tests natural product inhibitors of SIRT1 to enhance muscle hypertrophy, finding a 62% increase in fiber cross-sectional area with an optimal combination.

Impaired BCAA catabolism during adipocyte differentiation decreases glycolytic flux

This study shows that impairing BCAA catabolism during adipocyte differentiation reduces glycolytic flux and alters metabolic pathways in adipocytes.

Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

This study shows that LMNA mutations in iPSC-derived cardiomyocytes cause nuclear shape changes, reduced stiffness, and lamin mislocalization, linking nuclear abnormalities to LMNA-DCM pathogenesis.

Fast slow folding of an Outer Membrane Porin

The paper measures the real-time folding of an outer membrane porin using single-molecule Forster Resonance Energy Transfer, revealing fast folding events despite slow ensemble kinetics.

Microbiota control of maternal behavior regulates early postnatal growth of offspring

The paper identifies an E. coli strain that affects maternal behavior through microbiota-host interactions, leading to offspring growth stunting via impaired IGF-1 signaling.

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function

This study uses in vivo proteomics and nutrient tracing to show age-related metabolic changes in pancreatic β-cells improve glucose-stimulated insulin secretion.