A. Ryan

Defining focal neuroendocrine differentiation as a transcriptionally distinct form of prostate cancer pathology characterized by the expression of androgen receptors

This study uses single-cell RNA sequencing to show that focal neuroendocrine differentiation (Focal NED) in prostate cancer is transcriptionally distinct, characterized by androgen receptor expression and unique transcriptional sub-populations.

Evaluation of Gene Set Enrichment Analysis (GSEA) tools highlights the value of single sample approaches over pairwise for robust biological discovery.

This study compares GSEA tools and finds single sample approaches better capture biological distinctions than pairwise methods in cancer recurrence analysis.

3D-Printable Non-invasive Head Immobilization System for Non-Human Primates

This paper introduces a 3D-printable non-invasive head immobilization system for macaques, showing comparable gaze precision and accuracy to traditional headposts.

Fawn bedsite selection by a large ungulate living in a peri-urban area

This study examines how female fallow deer select birthing sites in response to human and dog presence in an urban park, finding they avoid high-traffic areas and prefer dense vegetation.

First Eurasian cases of SARS-CoV-2 seropositivity in a free-ranging urban population of wild fallow deer

The paper reports the first cases of SARS-CoV-2 seropositivity in Eurasian fallow deer, showing increased seroprevalence with emerging variants.

CRISPR-Cas9 editing induces Loss of Heterozygosity in the pathogenic yeast Candida parapsilosis

This study shows CRISPR-Cas9 editing in Candida parapsilosis can induce loss of heterozygosity and aneuploidy, highlighting the need for mutation complementation to confirm phenotypic changes.

Neonate personality affects early-life resource acquisition in a large social mammal

The paper examines how neonate personality traits in fallow deer influence resource acquisition strategies during early life, finding a trade-off between scanning and foraging time that develops over time.

Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates

This paper evaluates an AAV-based COVID-19 vaccine in mice and non-human primates, showing sustained neutralizing antibodies and memory T-cells, with room-temperature stability and scalable production.

Single Cell Transcriptomics-guided Antisense Treatment Improves Endoderm Differentiation of iPSCs

The paper develops a method to enhance endoderm differentiation of iPSCs by suppressing transcription factors identified through single-cell RNA sequencing, increasing endodermal cell yield by up to 20-fold.

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

Vaccine antigen, Factor H binding protein, is typically a non-lipidated precursor that localises to the meningococcal surface by Slam.

The paper shows that a non-lipidated precursor of Factor H binding protein is surface-localized by Slam in meningococcal isolates, challenging the assumption of lipidation for all isolates.