I. L. Bergin

Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis

This study shows that intestinal inflammation in a mouse model alters microbiota composition, increasing susceptibility to C. difficile colonization, and that reducing inflammation restores colonization resistance.

The gut bacterial community potentiates Clostridioides difficile infection severity

This study shows that gut bacterial communities influence the severity of Clostridioides difficile infections in mice, with certain bacterial groups linked to more or less severe outcomes.

An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance

This study shows that PEG laxative treatment in mice increases susceptibility to C. difficile colonization and delays clearance.

Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

This study shows pre-colonization with a less virulent C. difficile strain reduces germination of a lethal strain by limiting glycine availability, offering a mechanism for protective intraspecies competition.

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to Clostridioides difficile colonization and infection

This study shows that intestinal inflammation and altered gut microbiota in IBD make mice susceptible to C. difficile colonization and infection, highlighting the role of IBD-induced microbiota in disease severity.

Aging dampens the intestinal innate immune response during Clostridioides difficile infection and is associated with altered intestinal eosinophil mobilization

This study shows that aging impairs the intestinal innate immune response to C. difficile infection, leading to increased disease severity and altered eosinophil mobilization.

Effects of the copper IUD on composition of the vaginal microbiota in the olive baboon

This study examines the effects of copper IUD insertion, use, and removal on the vaginal microbiota and physiology of olive baboons, finding no significant microbiome changes during use but perturbations after removal.