Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease
I. Lindeman, L. S. Hoydahl, A. Christophersen, L. F. Risnes, J. Jahnsen, K. E. A. Lundin, L. M. Sollid, R. Iversen
The paper identifies circulating TG2-specific IgA cells in celiac disease patients, showing they are clonally related to intestinal plasma cells and generated via an extrafollicular response involving gluten-specific CD4+ T cells.
bioRxiv · Oct 20, 2023Immunology