Author

J. Shields

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

M. Joyce· 3 shared A. Riedel· 2 shared D. L. Tyrrell· 2 shared E. Arutyunova· 2 shared M. J. Lemieux· 2 shared A. Chomka· 1 shared A. Jakubowski· 1 shared A. Landi· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

M. Joyce

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Lymph node-targeted vaccine boosting of TCR-T cell therapy enhances anti-tumor 1 function and eradicates solid tumors

D. J. Drakes, A. M. Abbas, J. Shields, M. P. Steinbuck, A. Jakubowski, L. M. Seenappa, C. M. Haqq, P. C. DeMuth

This paper shows that combining AMP-vaccination with TCR-T cell therapy improves T cell persistence and anti-tumor activity, leading to solid tumor eradication in mice.

bioRxiv · May 5, 2022 · PreprintImmunology

Simulating the Tumor Microenvironment for Immune Cell Interactions via Deployable Extrusion Bioprinting

C. Mazzaglia, Y. Sheng, L. N. Rodrigues, I. M. Lei, J. Shields, Y. Y. S. Huang

The paper introduces a deployable extrusion bioprinting platform for creating 3D tumor microenvironments to study immune cell interactions and cancer drug testing.

bioRxiv · Apr 8, 2022 · PreprintBioengineering

SARS-COV-2 Recombinant Receptor-Binding-Domain (RBD) Induces Neutralising Antibodies Against Variant Strains of SARS-CoV-2 and SARS-CoV-1

J. L. M. Law, M. Logan, M. Joyce, A. Landi, D. Hockman, K. Crawford, J. Johnson, G. LaChance, H. Saffran, J. Shields, E. Hobart, R. Brassard, E. Arutyunova, K. Pabbaraju, M. Croxen, , M. Houghton

This study shows that recombinant SARS-CoV-2 RBD induces neutralizing antibodies against variant strains and SARS-CoV-1, suggesting its potential as a vaccine candidate or booster.

bioRxiv · May 10, 2021Microbiology

Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2

S. Shahbaz, L. Xu, M. Osman, W. Sligl, J. Shields, M. Joyce, L. Tyrrell, O. Oyegbami, S. Elahi

The paper shows that CD45+CD71+ erythroid cells in COVID-19 patients express SARS-CoV-2 entry factors and are immunosuppressive, suggesting their involvement in hypoxia and erythropoiesis disruption.

bioRxiv · Aug 18, 2020Immunology

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

W. Vuong, M. B. Khan, C. Fischer, E. Arutyunova, T. Lamer, J. Shields, H. A. Saffran, R. T. McKay, M. J. van Belkum, M. Joyce, H. S. Young, D. L. Tyrrell, J. C. Vederas, M. J. Lemieux

This paper shows that feline coronavirus drugs inhibit SARS-CoV-2 main protease and block virus replication in cell culture with low toxicity.

bioRxiv · May 3, 2020Biochemistry

Tumor pre-conditioning of draining lymph node stroma by lactic acid

A. Riedel, J. Swietlik, D. Shorthouse, L. Haas, T. Young, A. S. H. Costa, S. Davidson, L. Pedro, T. Oskarsson, B. A. Hall, C. Frezza, J. Shields

This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.

bioRxiv · Oct 12, 2018Cancer Biology

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

R. J. Miragaia, T. Gomes, A. Chomka, L. Jardine, A. Riedel, A. N. Hegazy, I. Lindeman, G. Emerton, T. Krausgruber, J. Shields, M. Haniffa, F. Powrie, S. A. Teichmann

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.

bioRxiv · Nov 22, 2017Immunology