A. Riedel

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.

Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

The paper identifies four secreted factors from metastasis-associated endothelial cells that promote breast cancer metastasis by enhancing cancer cell stemness and survival, with perivascular macrophages mediating this effect via the TNC-TLR4 axis.

A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

The paper shows that an insect beta-glucosidase metabolizes a dandelion defense compound, reducing its toxicity and altering herbivore feeding preference.

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

Tumor pre-conditioning of draining lymph node stroma by lactic acid

This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.