F. Powrie

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitis

This study shows Blimp-1 and c-Maf regulate gene networks in T cells to prevent colitis, with distinct roles in controlling inflammatory pathways in mouse models.

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

This study shows that intestinal epithelial cells expressing MHC II modulate CD4 T cell responses during intestinal inflammation, dampening pro-inflammatory effector Th cells.

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

Intestinal lamina propria supports acquired eTreg suppressor function

This study identifies spatially compartmentalized Treg subsets in the gut, showing that lamina propria supports acquired eTreg suppressor function through specific interactions with IL-1β+ macrophages and ILC2.

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions

This study investigates how TCR and inflammatory signals shape human MAIT cell functions, revealing their roles in tissue repair and effector responses.

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.