Author

I. M. Boekhoud

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

W. K. Smits· 3 shared E. J. Kuijper· 2 shared I. M. J. G. Bos-Sanders· 2 shared A.-M. Michel· 1 shared B. Spittal· 1 shared C. Harmanus· 1 shared COMBACTE-CDI Consortium· 1 shared D. Jahn· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

W. K. Smits

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3 papers

Recent·Most cited

MicrobiologybioRxivNov 18, 2020

Heme is crucial for medium-dependent metronidazole resistance in clinical isolates of C. difficile

I. M. Boekhoud, I. Sidorov, S. Nooij…·European Study Group for Clostridioides difficile

The paper shows heme dependence in metronidazole resistance in C. difficile clinical isolates, linked to a SNP in hsmA and associated with a resistant lineage.

DOI 10.1093/jac/dkab097

C. elegansDNA methylation

𝕏 PostBluesky

MicrobiologybioRxivJul 16, 2020

Redefining the Clostridioides difficile σB regulon: σB activates genes involved in detoxifying radicals that can result from the exposure to antimicrobials and hydrogen peroxide

I. M. Boekhoud, A.-M. Michel, J. Corver…·W. K. Smits

This study identifies genes directly regulated by σB in C. difficile and shows that antimicrobials and hydrogen peroxide induce these genes via σB-dependent mechanisms.

DOI 10.1128/msphere.00728-20

C. elegansexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivSep 21, 2018

Genome location dictates the transcriptional response to PolC-inhibition in Clostridium difficile

E. van Eijk, I. M. Boekhoud, E. J. Kuijper…·W. K. Smits

This study shows that genome location influences the transcriptional response to PolC-inhibition in C. difficile, with origin-proximal genes being more upregulated.

DOI 10.1128/aac.01363-18

C. eleganswhole-genome sequencing

𝕏 PostBluesky