BiochemistrybioRxiv
Mechanistic insights into the deleterious role of nasu-hakola disease associated TREM2 variants
R. Dash, H. J. Choi, I. S. Moon
This study investigates how three NHD-associated TREM2 mutations affect protein structure and function through molecular dynamics simulations, revealing structural changes and loss of ligand binding.
DOI 10.1038/s41598-020-60561-x