Author

I. Sarropoulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Organism:human· 4 Assay:scRNA-seq· 4 Research Focus:differential expression· 3 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Approach:biophysical modeling· 1 Research Focus:clustering· 1

Frequent Co-Authors

H. Kaessmann· 4 shared K. Okonechnikov· 4 shared L. M. Kutscher· 4 shared M. Sepp· 4 shared P. Joshi· 4 shared S. M. Pfister· 4 shared A. Korshunov· 3 shared D. T. W. Jones· 3 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

H. Kaessmann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

P. Joshi, P. B. G. da Silva, K. Okonechnikov, T. Stelzer, I. Sarropoulos, M. Sepp, J. Nolle, M. V. Pour-Jamnani, A. Rademacher, T. Yamada, C. Schneider, J. Schmidt, L. Bianchini, P. Schaefer, K. Leiss, , L. M. Kutscher

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

bioRxiv · Feb 9, 2024 · PreprintCancer Biology

Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance

K. Okonechnikov, P. Joshi, V. Koerber, A. Rademacher, M. Bortolomeazzi, J.-P. Mallm, P. B. G. da Silva, B. Statz, M. Sepp, I. Sarropoulos, T. Yamada-Saito, J. Vaillant, A. Wittmann, K. Schramm, M. Blattner-Johnson, , S. M. Pfister

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

bioRxiv · Feb 9, 2024Cancer Biology

Cellular development and evolution of the mammalian cerebellum

M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, K. Okonechnikov, P. Joshi, E. Leushkin, N. Mbengue, C. Schneider, J. Schmidt, N. Trost, L. Spaenig, P. Giere, P. Khaitovich, S. Lisgo, , H. Kaessmann

This study uses single-nucleus RNA-sequencing to compare cerebellar development across human, mouse, and opossum, revealing conserved and species-specific gene expression patterns.

bioRxiv · Dec 20, 2021Evolutionary Biology

Mapping pediatric brain tumors to their origins in the developing cerebellum

K. Okonechnikov, P. Joshi, M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, M. Sill, P. Beck, K. C.-H. Chan, A. Korshunov, F. Sahm, M. Y. Deng, D. Sturm, J. DeSisto, A. M. Donson, , S. M. Pfister

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

bioRxiv · Dec 19, 2021Cancer Biology