Author

J. DeSisto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. L. Green· 3 shared B. A. Orr· 2 shared A. Donson· 1 shared A. Korshunov· 1 shared A. Liu· 1 shared A. M. Donson· 1 shared A. von Deimling· 1 shared B. Sanford· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

A. L. Green

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Author profile →

3 papers

Recent·Most cited

Comprehensive Assessment of Blood-Brain Barrier Opening and Sterile Inflammatory Response: Unraveling the Therapeutic Window

P. J. Martinez, J. J. Song, F. G. Garay, K.-H. Song, T. Mufford, J. Steiner, J. DeSisto, N. Ellens, N. J. Serkova, A. L. Green, M. A. Borden

This study examines how microbubble volume doses and ultrasound mechanical indices affect BBB opening and sterile inflammation in mice, identifying a therapeutic window to optimize safe drug delivery.

bioRxiv · Oct 23, 2023Bioengineering

Mapping pediatric brain tumors to their origins in the developing cerebellum

K. Okonechnikov, P. Joshi, M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, M. Sill, P. Beck, K. C.-H. Chan, A. Korshunov, F. Sahm, M. Y. Deng, D. Sturm, J. DeSisto, A. M. Donson, , S. M. Pfister

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

bioRxiv · Dec 19, 2021Cancer Biology

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

J. DeSisto, J. T. Lucas, K. Xu, A. Donson, T. Lin, B. Sanford, Q. T. Tran, D. Hedges, C.-Y. Hsu, G. T. Armstrong, M. Arnold, S. Bhatia, P. Flannery, R. Lemma, L. Hardie, , A. L. Green

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.

bioRxiv · Oct 29, 2019 · PreprintCancer Biology