M. Bortolomeazzi

The paper uses single-cell transcriptomics to show how two compartments in medulloblastoma are connected through a migrating precursor stage, revealing spatial and developmental links between proliferating and differentiated tumor cells.

The paper assesses genes driving cancer and somatic evolution, revealing gaps in driver gene compendiums and identifying conserved genes that promote clonal expansion without malignancy.

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.

The paper curates a comprehensive list of 2,372 cancer-related genes from 275 publications, including sequencing screens of 119 cancer types, and provides annotations on their properties.