M. Liesa

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.

Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models

Mitoquinone mesylate shows antiviral and anti-inflammatory effects against SARS-CoV-2 in preclinical models.

Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes

This study uses CRISPR-Cas9 to create syngeneic iPSC-derived hepatocytes with ZAAT heterozygosity, revealing metabolic dysregulation and cellular heterogeneity in MZ and ZZ cells.

High-Throughput Image Analysis of Lipid-Droplet-Bound Mitochondria

The paper introduces a machine learning method to segment mitochondria in BAT images, revealing differences in H2O2 production between cytosolic and peri-droplet mitochondria.

Blocking mitochondrial pyruvate import causes energy wasting via futile lipid cycling in brown fat

The paper shows that blocking mitochondrial pyruvate import increases ATP synthesis via futile lipid cycling in brown adipocytes, enhancing energy expenditure without adrenergic stimulation.

Cristae undergo continuous cycles of fusion and fission in a MICOS-dependent manner

The paper uses live-cell imaging to show mitochondrial cristae undergo continuous fusion and fission, dependent on MIC13, with dynamics similar to crista junctions.

NCLX prevents cell death during adrenergic activation of the brown adipose tissue

This study identifies NCLX as a critical mitochondrial Na+/Ca2+ exchanger that prevents cell death during adrenergic activation of brown adipose tissue by mitigating Ca2+ overload.