Keratin 8 is a scaffolding and regulatory protein of ERAD complexes
I. M. Pranke, B. Chevalier, A. Premchandar…·A. Edelman
This study shows that Keratin 8 modulates ERAD complexes, enhancing degradation of misfolded proteins like Z-A1AT and F508del-CFTR, and suggests targeting K8 for therapeutic intervention in A1ATD.