Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR
D. F. Gauto, P. Macek, D. Malinverni, H. Fraga, M. Paloni, I. Sucec, A. Hessel, J. P. Bustamante, A. Barducci, P. Schanda
The paper uses MAS NMR and computational methods to show a flexible loop in TET2 aminopeptidase is critical for catalytic function and substrate processing.
bioRxiv · Jun 29, 2021Biophysics