Author

I. T. Mathews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. D. Watrous· 2 shared M. Jain· 2 shared Q. Ye· 2 shared R. K. Lau· 2 shared A. T. Whiteley· 1 shared B. Lowey· 1 shared C. S. Azimi· 1 shared J. J. Mekalanos· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

J. D. Watrous

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2 papers

Recent·Most cited

BiochemistrybioRxivJul 7, 2019

Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

R. K. Lau, Q. Ye, L. Patel…·K. Corbett

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

DOI 10.1016/j.molcel.2019.12.010

bacteria (other)proteomics

𝕏 PostBluesky

BiochemistrybioRxivJul 6, 2019

HORMA domain proteins and a Pch2-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity

Q. Ye, R. K. Lau, I. T. Mathews…·K. D. Corbett

The paper identifies a bacterial immunity pathway involving HORMA domain proteins, a cGAS-like enzyme, and a Pch2-like ATPase that mediates bacteriophage defense by generating a cyclic tri-AMP second messenger.

DOI 10.1016/j.molcel.2019.12.009

bacteria (other)experimental assay

𝕏 PostBluesky