M. Jain

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

Functionally selective dopamine D1 receptor endocytosis and signaling by catechol and non-catechol agonists

This paper investigates how catechol and non-catechol dopamine D1 receptor agonists induce different signaling and endocytosis patterns, showing that functional selectivity impacts receptor internalization.

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

AlphaFold2 structures template ligand discovery

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

Structure-Based Discovery of a NPFF1R Antagonist with Analgesic Activity

This paper identifies a selective NPFF1R antagonist with analgesic properties, showing enhanced pain relief when combined with morphine and reduced side effects.

Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

The paper identifies profibrotic monocyte-derived alveolar macrophages and neutrophil recruitment as drivers of lung fibrosis in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

This study shows that lactational exposure to Triclosan in mice causes fatty liver disease by disrupting metabolic pathways involving PERK-eIF2-ATF4-PPAR.

An integrated cell atlas of the human lung in health and disease

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.

BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes

Non-invasive Chromatin Deformation and Measurement of Differential Mechanical Properties in the Nucleus

This paper uses localized temperature gradients to measure nuclear mechanical properties, revealing distinct material responses in different compartments.

Decidual immune response following COVID-19 during pregnancy varies by timing of maternal SARS-CoV-2 infection

This study examines how the timing of maternal SARS-CoV-2 infection during pregnancy affects the decidual immune response, finding differences in immune cell abundance and cytokine expression between early and late gestation infections.

Temporal variation in the behaviour of a cooperatively breeding bird, Jungle Babbler (Argya striata) at diel and seasonal scale

This study examines how Jungle Babbler behavior varies across diel and seasonal scales, finding that most time is spent on individual behaviors and that behavior proportions change with environmental conditions.

ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection

The paper develops a monoclonal antibody cocktail (ZRC-3308) effective against multiple SARS-CoV-2 variants in Syrian hamsters.

Direct Nanopore Sequencing of Individual Full Length tRNA Strands

This paper describes a method for direct tRNA sequencing using Oxford Nanopore MinION, achieving 76-92% full-length reads and detecting all 42 tRNA isoacceptors in E. coli.

Song complexity in relation to repertoire size and phonological syntax in the breeding song of Purple Sunbird

The paper examines song complexity in Purple Sunbirds by analyzing repertoire size, phonological syntax, and vocal mechanisms.

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

Inflammation Drives Alternative First Exon usage to Regulate Immune Genes including a Novel Iron Regulated Isoform of Aim2

The paper identifies inflammation-induced alternative first exon usage in immune genes, revealing a novel iron-regulated Aim2 isoform with a 5′UTR iron-responsive element.

Genome-Wide High Resolution Expression Map and Functions of Key Cell Fate Determinants Reveal the Dynamics of Crown Root Development in Rice

The paper identifies key regulators of crown root development in rice and reveals conserved mechanisms across plant species.

Effect of temperature on life-history traits and mating calls of a field cricket, Acanthogryllus asiaticus

This study examines how developmental and ambient temperatures affect life-history traits and mating calls in Acanthogryllus asiaticus field crickets, finding temperature-induced changes in body size, lifespan, and call characteristics.

Mapping Gene-Microbe Interactions: Insights from Functional Genomics Co-culture Experiments between Saccharomyces cerevisiae and Pseudomonas spp.

The paper identifies gene-microbe interactions in co-cultures of Saccharomyces cerevisiae and Pseudomonas spp., showing that 643 genes show fitness differences, with 36% of interactions not replicable in cell-free experiments.

Structural and functional complexity of vocalizations in a cooperatively breeding passerine, Jungle Babbler

This study examines vocal complexity in Jungle Babblers, finding a diverse repertoire of 15 calls with structural complexity and a disproportionate use in vigilance contexts, supporting the social complexity hypothesis.

Mapping metabolic oscillations during cell cycle progression

The paper identifies metabolic oscillations during the cell cycle in HeLa cells using metabolomics, revealing stage-specific changes in metabolites and suggesting new metabolic activities linked to cell cycle progression.

Single-cell RNA-seq reveals spatially restricted multicellular fibrotic niches during lung fibrosis

The paper identifies monocyte-derived alveolar macrophages as causally linked to fibrosis in lung tissue through autocrine signaling and fibroblast activation.

Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

HORMA domain proteins and a Pch2-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity

The paper identifies a bacterial immunity pathway involving HORMA domain proteins, a cGAS-like enzyme, and a Pch2-like ATPase that mediates bacteriophage defense by generating a cyclic tri-AMP second messenger.

Whole cell response to receptor stimulation involves many deep and distributed subcellular processes

The paper identifies subcellular processes involved in cannabinoid-1 receptor regulated neurite outgrowth and shows they are distributed and deep.

Resolving the complex Bordetella pertussis genome using barcoded nanopore sequencing

This paper demonstrates the use of barcoded nanopore sequencing and optimized assembly pipelines to resolve complex Bordetella pertussis genomes, revealing inter-strain genomic rearrangements and challenges with highly duplicated regions.

A systems biology approach to explore the impact of maple tree dormancy release on sap variation and maple syrup quality

The paper investigates sap composition changes during maple tree dormancy release and links them to syrup quality and the buddy defect using amino acid analysis and yeast competition assays.