Author

L. Patel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. T. Whiteley· 1 shared B. Lowey· 1 shared D. M. Owen· 1 shared D. Williamson· 1 shared E. A. K. Cohen· 1 shared E. Cohen· 1 shared I. T. Mathews· 1 shared J. D. Watrous· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. T. Whiteley

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Author profile →

4 papers

Recent·Most cited

Inferring pathways of oxidative folding from pre-folding free energy landscapes of disulfide-rich toxin

R. A. Mansbach, L. Patel, N. A. Watson, J. Z. Kubicek-Sutherland, S. Gnanakaran

This study uses diffusion maps to analyze the free energy landscapes of micro-conotoxins, revealing how sequence and length influence folding pathways and disulfide bond formation.

bioRxiv · Oct 7, 2022 · PreprintBiophysics

Blinking Statistics and Molecular Counting in direct Stochastic Reconstruction Microscopy (dSTORM)

L. Patel, D. Williamson, D. M. Owen, E. A. K. Cohen

The paper develops a method to accurately count molecules in dSTORM microscopy by modeling photo-switching as a Markov process and demonstrates it on T cell LAT proteins.

bioRxiv · Feb 2, 2021Biophysics

Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

R. K. Lau, Q. Ye, L. Patel, K. R. Berg, I. T. Mathews, J. D. Watrous, A. T. Whiteley, B. Lowey, J. J. Mekalanos, P. J. Kranzusch, M. Jain, K. Corbett

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

bioRxiv · Jul 7, 2019Biochemistry

A hidden Markov model approach to characterizing the photo-switching behavior of fluorophores

L. Patel, N. Gustafsson, Y. Lin, R. Ober, R. Henriques, E. Cohen

The paper uses a hidden Markov model to characterize fluorophore photo-switching behavior by estimating transition rates from image sequences.

bioRxiv · Nov 22, 2017Biophysics