Author

J. Eldstrom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Approach:experimental assay· 2 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Fedida· 3 shared A. de La Cruz· 1 shared A. Golluscio· 1 shared D. P. Tieleman· 1 shared D. Sastre· 1 shared H. Sahakyan· 1 shared I.-S. Chen· 1 shared J. J. Jowais· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

D. Fedida

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PUFA stabilizes a conductive state of the selectivity filter in IKs channels

A. Golluscio, J. Eldstrom, J. J. Jowais, M. E. Perez, K. P. Cunningham, A. de La Cruz, X. Wu, D. Fedida, P. Larsson, D. P. Tieleman, V. Corradi

This study investigates how PUFAs stabilize the selectivity filter of IKs channels, increasing their conductance and potentially treating Long QT Syndrome.

bioRxiv · Jan 11, 2024Biophysics

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

M. Chan, H. Sahakyan, J. Eldstrom, D. Sastre, Y. Wang, Y. Dou, M. Pourrier, V. Vardanian, D. Fedida

The paper identifies a generalized binding pocket for small molecule IKs activators at the extracellular interface of KCNQ1 and KCNE1 channel complexes, explaining their mechanism and guiding future drug design.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel

I.-S. Chen, J. Eldstrom, D. Fedida, Y. Kubo

This study identifies a novel ion-conducting pathway in a GIRK channel mutant, showing it allows Li+ permeation independent of the selectivity filter.

bioRxiv · Aug 18, 2021Physiology