Cancer BiologybioRxiv
A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth
Iratxe Zuazo-Gaztelu, David Lawrence, Ioanna Oikonomidi…·Avi Ashkenazi
This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.
DOI 10.1371/journal.pbio.3003086