Avi Ashkenazi

This paper identifies ATF6α as a non-transcriptional regulator of peroxisome quality control through its interaction with ABCD3, and shows how this interaction can be modulated by Ceapin to influence cancer-related processes.

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

This study shows TRAIL induces caspase-dependent cleavage of AP2 and CHC, with AP2 cleavage requiring caspase-8 and CHC cleavage requiring both caspase-8 and caspase-3.

This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.