Isaac Grunow

Dietary sugar type determines the response to protein restriction in females, but not males

The paper shows that in female mice, carbohydrate quality affects metabolic and neurological responses to low protein diets, but not in males.

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice

This study shows that ovariectomy in female mice enhances their metabolic response to a low protein diet, aligning it with males, while castration has little effect on males.

Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimers disease in 3xTg mice

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

Ketogenesis is dispensable for the metabolic adaptations to caloric restriction

This study shows that ketogenesis is not essential for the metabolic benefits of caloric restriction in mice, as Hmgcs2 deletion does not impair key metabolic adaptations.

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer&aposs disease

This study shows that fasting, not just calorie reduction, is necessary for many benefits of caloric restriction in 3xTg mice with Alzheimer's disease.

Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids

This study shows that dietary BCAA restriction mitigates metabolic issues and cellular senescence in mice, with tissue-specific effects observed.

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.