Shoshana Yakar

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

This study investigates how canagliflozin affects brain aging and Alzheimer's-like pathology in mice, finding sex-specific effects on hippocampal function and disease markers.

This study investigates the impact of AIM2 gene deletion on bone morphology in mice, finding increased cortical thickness and decreased trabecular bone volume and BMD in aged AIM2 null females.

This study examines primary osteoarthritis in aged UM-HET3 mice, finding sex-specific effects of MB and MitoQ treatments and correlations between cartilage scores and inflammation, cell cycle markers, and subchondral bone changes.