Author

J. A. Corcoran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Kleer· 4 shared C.-A. Robinson· 3 shared E. L. Castle· 3 shared M. P. Bui-Marinos· 2 shared R. P. Mulloy· 2 shared A. Banerjee· 1 shared A. Dufour· 1 shared A. Jaffer· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

M. Kleer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation

S. M. Dolliver, M. Kleer, M. P. Bui-Marinos, S. Ying, J. A. Corcoran, D. Khaperskyy

This study shows that HCoV-OC43 and SARS-CoV2 inhibit stress granule formation through viral proteins N and Nsp1, with Nsp1 also reducing G3BP1 levels and causing nuclear retention of TIAR.

bioRxiv · May 2, 2022Microbiology

A panel of KSHV mutants in the polycistronic kaposin locus for precise analysis of individual protein products

M. Kleer, G. MacNeil, E. S. Pringle, J. A. Corcoran

The paper creates a panel of KSHV mutants to analyze the individual roles of kaposin proteins in viral replication and pathogenesis.

bioRxiv · Jun 11, 2021Microbiology

Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies

C.-A. Robinson, G. K. Singh, M. Kleer, E. L. Castle, B. Q. Boudreau, J. A. Corcoran

This paper shows KSHV uses the NDP52/CALCOCO2 autophagy receptor to disassemble processing bodies, enhancing inflammation during infection.

bioRxiv · Feb 7, 2021Cell Biology

SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients

N. L. Rosin, A. Jaffer, S. Sinha, R. P. Mulloy, C. Robinson, E. Labit, L. G. Almeida, A. Dufour, J. A. Corcoran, B. Yipp, J. Biernaskie

The paper investigates whether SARS-CoV-2 uses circulating immune cells to spread in severe COVID-19 patients and finds that these cells are not actively infected and not a source of viral dissemination.

bioRxiv · Jan 19, 2021 · PreprintImmunology

Human coronaviruses disassemble processing bodies

M. Kleer, R. P. Mulloy, C.-A. Robinson, D. Evseev, M. P. Bui-Marinos, E. L. Castle, A. Banerjee, S. Mubareka, K. Mossman, J. A. Corcoran

This study shows SARS-CoV-2 and related coronaviruses induce processing body disassembly, with SARS-CoV-2's N protein uniquely causing this effect, leading to increased proinflammatory cytokine production.

bioRxiv · Nov 8, 2020Microbiology

Viral manipulation of mechanoresponsive signaling disassembles processing bodies

E. L. Castle, C.-A. Robinson, P. Douglas, K. D. Rinker, J. A. Corcoran

The paper shows that mechanical forces and YAP activation induce PB disassembly through actin rearrangements, using KapB as a tool to uncover this mechanism.

bioRxiv · May 15, 2020Cell Biology