SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients
N. L. Rosin, A. Jaffer, S. Sinha, R. P. Mulloy, C. Robinson, E. Labit, L. G. Almeida, A. Dufour, J. A. Corcoran, B. Yipp, J. Biernaskie
Abstract
In late 2019 a novel coronavirus (SARS-CoV-2) emerged, and has since caused a global pandemic. Understanding the pathogenesis of COVID-19 disease is necessary to inform development of therapeutics, and management of infected patients. Using scRNAseq of blood drawn from SARS-CoV-2 patients, we asked whether SARS-CoV-2 may exploit immune cells as a Trojan Horse to disseminate and access multiple organ systems. Our data suggests that circulating cells are not actively infected with SARS-CoV-2, and do not appear to be a source of viral dissemination.
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