D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability
G. Rona, B. Miwatani-Minter, Q. Zhang, H. V. Goldberg, M. A. Kerzhnerman, J. B. Howard, D. Simoneschi, E. Lane, J. W. Hobbs, E. Sassani, A. A. Wang, S. Keegan, D. J. Laverty, C. G. Piett, L. S. Pongor, , M. Pagano
This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.
bioRxiv · Jan 12, 2024Cell Biology