S. Nayak

The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular senescence and drug resilience.

This study identifies artemisinin-induced dormant stages of Plasmodium falciparum as exhibiting senescence-like features and drug resistance.

WDR82 mediated H3K4me3 is associated with tumor proliferation and therapeutic efficacy in pediatric high-grade gliomas

The paper shows that WDR82-mediated H3K4me3 promotes tumor proliferation and affects therapeutic response in pediatric high-grade gliomas.

Novel insights into Entamoeba cyst wall formation and the importance of actin cytoskeleton

This study investigates the morphological stages of chitin wall formation in Entamoeba invadens, revealing the role of chitin synthase and actin cytoskeleton dynamics in cyst wall development.

Identification of PIM1 substrates reveals a role for NDRG1 in prostate cancer cellular migration and invasion

This study identifies PIM1 substrates in prostate cancer cells, revealing that PIM1 phosphorylates NDRG1, reducing its stability and function in suppressing cell migration and invasion.

Replication gaps are a cancer vulnerability counteracted by translesion synthesis

The paper identifies that oncogene expression creates replication gaps, which are suppressed by translesion synthesis (TLS), and shows that inhibiting TLS reduces cancer cell fitness.

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.

Replication gaps underlie BRCA-deficiency and therapy response

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.

Unique PKD like protein kinase in Entamoeba histolytica regulates vital actin mediated processes

This study identifies and characterizes EhPKDL, a PKD-like protein kinase in Entamoeba histolytica that nucleates actin polymerization and is essential for actin-mediated processes like erythrophagocytosis.

Circadian control of lung inflammation in influenza infection

This study shows that circadian rhythms affect lung inflammation during influenza infection by influencing immune cell composition rather than viral replication.

LINE-1 and the cell cycle: protein localization and functional dynamics

This study identifies L1 protein nuclear entry mechanisms and shows a cell cycle bias for L1 retrotransposition peaking in S phase.