Author

J. LaCava

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. Fenyo· 3 shared H. Jiang· 3 shared I. Altukhov· 2 shared J. Boeke· 2 shared K. R. Molloy· 2 shared M. Oghbaie· 2 shared P. Mita· 2 shared W. McKerrow· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

D. Fenyo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

S. Sun, J. Hong, E. You, K. M. Tsanov, J. Chacon-Barahona, A. D. Gioacchino, D. Hoyos, H. Li, H. Jiang, H. Ly, S. A. Marhon, R. Murali, P. Chanda, A. Karacay, N. Vabret, , B. D. Greenbaum

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

bioRxiv · May 19, 2023 · PreprintCancer Biology

LINE-1 expression in cancer correlates with DNA damage response, copy number variation, and cell cycle progression

W. McKerrow, X. Wang, P. Mita, S. Cao, M. Grivainis, L. Ding, J. LaCava, J. Boeke, D. Fenyö

bioRxiv · Jun 26, 2020 · PreprintCancer Biology

Affinity proteomic dissection of the human nuclear cap-binding-complex interactome

Y. Dou, S. Kalmykova, M. Pashkova, M. Oghbaie, H. Jiang, K. R. Molloy, B. T. Chait, M. P. Rout, D. Fenyo, T. H. Jensen, I. Altukhov, J. LaCava

This study maps the human nuclear cap-binding complex interactome using affinity proteomics to clarify the composition and interactions of NCBP1, NCBP2, and NCBP3-related macromolecular assemblies.

bioRxiv · Apr 20, 2020Biochemistry

LINE-1 ORF2P EXPRESSION IS NEARLY IMPERCEPTIBLE IN HUMAN CANCERS

D. Ardeljan, X. Wang, M. Oghbaie, M. S. Taylor, D. Husband, V. Deshpande, J. P. Steranka, M. Gorbounov, W. R. Yang, B. Sie, H. B. Larman, H. Jiang, K. R. Molloy, I. Altukhov, Z. Li, , J. LaCava

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

bioRxiv · Aug 22, 2019Cancer Biology

LINE-1 and the cell cycle: protein localization and functional dynamics

P. Mita, A. Wudzinska, X. Sun, J. Andrade, S. Nayak, D. Kahler, S. Badri, J. LaCava, B. Ueberheide, C. Yun, D. Fenyo, J. Boeke

This study identifies L1 protein nuclear entry mechanisms and shows a cell cycle bias for L1 retrotransposition peaking in S phase.

bioRxiv · Jun 30, 2017Cell Biology