A. Kuo

Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy

The paper shows that activating endothelial S1PR1 with HDL-bound S1P or a Gi-biased agonist suppresses neovascular tufts in retinopathy models.

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

This paper constructs engineered HDL-like particles that chaperone bioactive lipids to reduce inflammation and endothelial dysfunction.

Crosstalk of Histone Modifications in the Healthy Human Immune System

The paper analyzes histone post-translational modifications in human immune cells to uncover their interactions and functional implications.

Characterization of a novel polyextremotolerant fungus, Exophiala viscosa, with insights into its melanin regulation and ecological niche

This study characterizes a novel polyextremotolerant fungus, Exophiala viscosa, revealing its metabolic flexibility, abiotic stress tolerance, and melanin production capabilities.

Within-Arctic horizontal gene transfer as a driver of convergent evolution in distantly related microalgae

The paper identifies horizontal gene transfer as a driver of convergent evolution in Arctic microalgae, highlighting ice-binding domain gene transfers between distantly related species.

LMO2 is critical for early metastatic events in breast cancer

The paper identifies LMO2-expressing tumor cells as metastasis-initiating cells and shows LMO2-STAT3 signaling promotes breast cancer metastasis.

Evolutionary priming and transition to the ectomycorrhizal habit in an iconic lineage of mushroom-forming fungi: is preadaptation a requirement?

This study identifies genomic features of the transition to ectomycorrhizal habit in Russulaceae fungi, finding gene loss, TE expansion, and secreted protein associations with TE nests.

Humans optimally anticipate and compensate for an uneven step during walking

This study shows humans use an energy-minimizing strategy to anticipate and compensate for uneven steps during walking, matching predictions from optimal control models.

Serial femtosecond and serial synchrotron crystallography yield data of equivalent quality: a systematic comparison

This study compares data quality from serial femtosecond and serial synchrotron crystallography for two proteins, finding equivalent quality regardless of radiation source.

A model-based analysis of the mechanical cost of walking on uneven terrain

The paper analyzes mechanical models of walking on uneven terrain, finding that push-off timing is more economical than hip power for maintaining speed.

Anticipatory Control of Momentum for Bipedal Walking on Uneven Terrain

The paper models bipedal walking on uneven terrain as an optimal control problem and finds that anticipatory momentum control reduces energy and peak power demands.

Suppressed Osteocyte Perilacunar / Canalicular RemodelingPlays a Causal Role in Osteoarthritis

This study shows that suppressed osteocyte perilacunar/canalicular remodeling causes osteoarthritis by impairing cartilage homeostasis in humans and mice.

Heterotypic inter-GPCR β-arrestin coupling regulates lymphatic endothelial junctional architecture in murine lymph nodes

The paper identifies LPAR1-induced S1PR1/β-arrestin coupling as a mechanism regulating lymphatic endothelial junctional architecture in murine lymph nodes.