T. Taylor

Competition between transcription and loop extrusion modulates promoter and enhancer dynamics

The paper investigates how transcription and loop extrusion interact to influence promoter and enhancer dynamics through live tracking and simulations.

The soil microbiome reduces Striga infection of sorghum by modulation of host-derived signaling molecules and root development

This study shows that the soil microbiome reduces Striga infection in sorghum by inducing root suberization, aerenchyma formation, and degrading haustorium-inducing factors.

Nanopore sequencing methods detect cell-free DNA associated with minimal residual disease and central nervous system infiltration in pediatric Acute Lymphoblastic Leukemia

This paper develops a nanopore sequencing method to detect B-ALL-associated cell-free DNA in blood and CSF, enabling early detection of MRD and CNS infiltration in pediatric ALL patients.

Cytolytic memory CD4+ T cell clonotypes are expanded during Plasmodium falciparum infection

The paper identifies clonally expanded cytolytic memory CD4+ T cells in Plasmodium falciparum malaria patients and links their reduced chemotactic and inhibitory receptor expression to clinical immunity.

Characterization of growth and development of sorghum genotypes with differential susceptibility to Striga hermonthica

This study shows that the lgs1 mutation in sorghum affects growth, development, and hormone levels beyond altering strigolactone exudation, impacting Striga resistance.

Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays

The paper improves the production of SARS-CoV-2 spike RBD for serology assays by optimizing DNA constructs, purification parameters, and demonstrating the role of a carboxyterminal tag in sensitivity.

REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters

This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

The paper determines crystal structures of KRAS mutants bound to RAF1 domains, revealing molecular interactions critical for RAS-mediated RAF activation.

Optimizing high-yield production of SARS-CoV-2 soluble spike trimers for serology assays

This study improves the yield of SARS-CoV-2 spike protein for serology assays by optimizing expression and purification parameters, achieving 5 mg/L production.

Recommendations for sample pooling on the Cepheid GeneXpert(R) system using the Cepheid Xpert(R) Xpress SARS-CoV-2 assay

The paper recommends sample pooling for the Cepheid Xpert Xpress SARS-CoV-2 assay to increase testing capacity during the pandemic, providing guidelines for optimal pooling depth based on test rates.

BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells.

This study shows that BET inhibition reduces aberrant RUNX1 and ERG transcription in STAG2 mutant leukemia cells by blocking enhancer-driven gene expression during differentiation.

Parasite histones mediate leak and coagulopathy in cerebral malaria

This study shows parasite histones contribute to coagulopathy and vascular leak in cerebral malaria, leading to brain swelling and poor outcomes.