Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins
S. Jeon, E. Scorletti, D. Buyco, C. Lin, Y. Saiman, J. Martin, R. Hooks, B. Ogretmen, J. Argemi, L. Melo, R. Bataller, R. M. Carr
This study shows that deleting CerS6 reduces alcohol-induced fatty liver and improves glucose homeostasis in mice, and links CerS6 expression to ALD progression in humans.
bioRxiv · Nov 3, 2022 · PreprintPathology