Author

L. Melo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. O. Henriques· 1 shared A. Rohlfing· 1 shared A. Shen· 1 shared B. Dupuy· 1 shared B. Ogretmen· 1 shared C. Feliciano· 1 shared C. Janoir· 1 shared C. Lin· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

A. O. Henriques

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-spore germination analyses reveal that calcium released during Clostridioides difficile germination functions in a feed-forward loop.

J. W. Ribis, L. Melo, S. Shrestha, D. Giacalone, E. E. Rodriguez, A. Shen, A. Rohlfing

This study uses single-spore germination analysis to show that Ca2+ is not essential for C. difficile spore germination but can enhance germination through a feedforward loop.

bioRxiv · Nov 11, 2022 · PreprintMicrobiology

Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins

S. Jeon, E. Scorletti, D. Buyco, C. Lin, Y. Saiman, J. Martin, R. Hooks, B. Ogretmen, J. Argemi, L. Melo, R. Bataller, R. M. Carr

This study shows that deleting CerS6 reduces alcohol-induced fatty liver and improves glucose homeostasis in mice, and links CerS6 expression to ALD progression in humans.

bioRxiv · Nov 3, 2022 · PreprintPathology

Structure and assembly of a Clostridioides difficile spore polar appendage

W. Antunes, F. C. Pereira, C. Feliciano, L. Saujet, T. d. Vultos, E. Couture-Tosi, S. Pechine, J.-F. Bruxelle, C. Janoir, L. Melo, P. Brito, I. Martin-Verstraete, M. Serrano, B. Dupuy, A. O. Henriques

This study investigates the structure and role of the polar appendage in Clostridioides difficile spores, showing its impact on germination and virulence.

bioRxiv · Dec 3, 2018 · PreprintMicrobiology