Author

D. Hacker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

F. Pojer· 2 shared K. Lau· 2 shared A. Fraenkli· 1 shared B. Correia· 1 shared D. Lainscek· 1 shared D. Ni· 1 shared D. Peterhoff· 1 shared F. Lehmann· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

F. Pojer

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2 papers

Recent·Most cited

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein

D. Ni, K. Lau, F. Lehmann, A. Fraenkli, D. Hacker, F. Pojer, H. Stahlberg

This study uses cryo-EM to show that hACE2 binding causes SARS-CoV-2 Spike trimer disassembly and S1 domain rearrangement, suggesting a mechanism for soluble hACE2's therapeutic effect.

bioRxiv · Oct 12, 2020 · PreprintBiophysics

Immune response to vaccine candidates based on different types of nanoscaffolded RBD domain of the SARS-CoV-2 spike protein

D. Lainscek, T. Fink, V. Forstneric, I. Hafner-Bratkovic, S. Orehek, Z. Strmsek, M. Mancek Keber, P. Pecan, H. Esih, S. Malensek, J. Aupic, P. Dekleva, T. Plaper, S. Vidmar, L. Kadunc, , R. Jerala

This study evaluates DNA vaccines with RBD domains scaffolded by different peptides, finding that the β-annulus scaffold elicits the strongest immune response in mice.

bioRxiv · Aug 28, 2020 · PreprintImmunology