Author

J. Benoit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Bioengineering· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

G. M. Attardo· 2 shared K. Oyen· 2 shared S. Aksoy· 2 shared V. Michalkova· 2 shared A. Baumann· 1 shared A. Fieler· 1 shared A. Kondragunta· 1 shared A. Malacrida· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

G. M. Attardo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Efficient and durable gene activation by Cas9-mediated epigenome editing in vivo

Y. Qin, T. Akbulut, R. Mandraju, K. Connolly, J. Bechill, F. Assadian, A. Shottek, S. Levy, J. Benoit, T. Yamagata

This paper demonstrates efficient and durable gene activation using Cas9-mediated epigenome editing in a mouse model of LAMA2-CMD, showing sustained therapeutic effects beyond one year.

bioRxiv · May 3, 2024 · PreprintBioengineering

Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis

G. M. Attardo, J. Benoit, V. Michalkova, A. Kondragunta, A. Baumann, B. Weiss, A. Malacrida, F. Scolari, S. Aksoy

This study shows that eliminating symbiotic bacteria in tsetse flies disrupts lipid metabolism via the Kennedy pathway, leading to reproductive failure.

bioRxiv · Aug 23, 2022Physiology

Warm blood meal increases digestion rate and milk protein production to maximize reproductive output for the tsetse fly, Glossina morsitans

J. Benoit, C. Lahondere, G. M. Attardo, V. Michalkova, K. Oyen, Y. Xiao, S. Aksoy

The study shows that warm blood meals in tsetse flies shorten pregnancy duration and increase milk protein production, enhancing reproductive output.

bioRxiv · Aug 7, 2022Physiology

NK cell metabolic adaptation to infection promotes survival and viral clearance.

F. Victorino, T. Bigley, E. Park, C.-H. Yao, J. Benoit, L.-P. Yang, S. J. Piersma, E. J. Lauron, R. M. Davidson, G. J. Patti, W. M. Yokoyama

This study shows HIF-1 is essential for NK cell survival and viral clearance during MCMV infection by regulating metabolism and preventing apoptosis.

bioRxiv · Mar 17, 2021Immunology

Larval thermal characteristics of multiple ixodid ticks underlie their range dynamics

A. Fieler, A. Rosendale, D. Farrow, M. Dunlevy, B. Davies, K. Oyen, J. Benoit

This study examines thermal characteristics of six ixodid tick larvae, finding variation in thermal tolerance, preference, activity, and metabolic rate, which are critical for predicting their geographic range under climate change.

bioRxiv · Dec 11, 2019 · PreprintPhysiology

Sex chromosome evolution in muscid flies

R. Meisel, P. Olafson, K. Adhikari, F. D. Guerrero, K. Konganti, J. Benoit

The paper compares sex chromosome evolution in muscid flies to determine why some species have divergent sex chromosomes while others conserve them.

bioRxiv · Sep 20, 2019Evolutionary Biology