S. Aksoy

Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer

This study identifies LINC00152 as a driver of tamoxifen resistance in ER+ breast cancer by inhibiting ferroptosis, and shows that targeting LINC00152 restores sensitivity to tamoxifen.

Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer

This study shows that T-DM1 induces immunogenic cell death (ICD) in HER2-positive breast cancer, which is lost in resistance, and that targeting TACC3 restores ICD and enhances T-DM1 response.

Cancer Prevalence Across Vertebrates

The paper analyzes cancer prevalence across 292 vertebrate species and finds that neoplasia prevalence increases with adult weight and mutation rate but decreases with gestation time.

Life history and cancer in birds: clutch size predicts cancer

This study investigates the relationship between life history traits and cancer prevalence in managed birds, finding that clutch size is positively correlated with cancer and neoplasia prevalence.

Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis

This study shows that eliminating symbiotic bacteria in tsetse flies disrupts lipid metabolism via the Kennedy pathway, leading to reproductive failure.

Warm blood meal increases digestion rate and milk protein production to maximize reproductive output for the tsetse fly, Glossina morsitans

The study shows that warm blood meals in tsetse flies shorten pregnancy duration and increase milk protein production, enhancing reproductive output.

Extravascular spaces are the primary reservoir of antigenic diversity in Trypanosoma brucei infection

The paper shows that extravascular spaces, not the bloodstream, are the main source of antigenic diversity in Trypanosoma brucei infections, with over 75% of VSGs found exclusively in these spaces.

Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis

This study investigates how Spiroplasma infection affects tsetse fly metabolism and reproduction, finding negative impacts on fecundity and sperm competitiveness.

Paratransgenic manipulation of tsetse miR275 alters the physiological homeostasis of the flys midgut environment

This study uses paratransgenesis to knock down miR275 in tsetse flies, showing it disrupts midgut physiology and trypanosome infection.

Thermal stress responses of Sodalis glossinidius, an indigenous bacterial symbiont of hematophagous tsetse flies

This study investigates the thermal stress responses of Sodalis glossinidius, a symbiont of tsetse flies, revealing its heat shock response mechanisms and thermal tolerance limits.

Colonization of the tsetse fly midgut with commensal Enterobacter inhibits trypanosome infection establishment

This study shows that colonizing tsetse flies with Enterobacter inhibits trypanosome infection and reduces susceptibility to entomopathogenic bacteria without significant fitness costs.

A fine-tuned vector-parasite dialogue in tsetse’s cardia determines peritrophic matrix integrity and trypanosome transmission success

The paper investigates how tsetse flies' peritrophic matrix integrity and trypanosome transmission success are regulated by interactions between the fly and parasite in the cardia.