S. Levy

Efficient and durable gene activation by Cas9-mediated epigenome editing in vivo

This paper demonstrates efficient and durable gene activation using Cas9-mediated epigenome editing in a mouse model of LAMA2-CMD, showing sustained therapeutic effects beyond one year.

EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

This study shows EGFR-mutant lung adenocarcinomas exploit alveolar macrophage metabolism via GM-CSF--PPARγ signaling to support tumor growth and EGFR signaling, suggesting new therapeutic strategies combining statins and PPARγ inhibition.

Discovery of the gut microbial enzyme responsible for bilirubin reduction to urobilinogen

This study identifies BilR, a gut microbial enzyme that reduces bilirubin to urobilinogen, and shows its prevalence in healthy adults and decline in neonates and IBD patients.

Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer

This study establishes patient-derived tumor organoids (PDTOs) for neuroendocrine cancers, identifies therapeutic vulnerabilities, and highlights EGF dependency in pulmonary neuroendocrine tumors.

Origin and dynamics of Mycobacterium tuberculosis subpopulations that predictably generate drug tolerance and resistance

This paper identifies drug-tolerant subpopulations in Mycobacterium tuberculosis using a multi-transwell system and barcoding, showing their role in generating resistance.

Genetic determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo

This study investigates how genetic alterations affect EGFR-driven lung cancer growth and therapy response using a mouse model and CRISPR-Cas9 editing.

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

This study identifies systemic tissue and cellular disruption from SARS-CoV-2 infection using autopsy and spatial omics data, showing tissue-specific damage and transcriptional changes.

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote beta cell regeneration

Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA

This study identifies 5-hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA to detect early-stage pancreatic cancer with high accuracy.

Single-cell copy number variant detection reveals the dynamics and diversity of adaptation

This study detects single-cell copy number variants (CNVs) in evolving populations and identifies ODIRA as a common mechanism for gene amplification.

Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration ofinflammatory immune cells in EGFR mutant lung tumors

The paper shows that erlotinib and oncogene withdrawal in EGFR mutant lung tumors increase infiltration of inflammatory immune cells, suggesting immunostimulatory effects of tumor regression.