Author

J. Binder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

C. Steppan· 2 shared R. O'Connor· 2 shared A. Anderson· 1 shared A. D. Mesecar· 1 shared A. Herrera· 1 shared A. K. Chatterjee· 1 shared A. Mohamed· 1 shared A. S. Anderson· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Steppan

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2 papers

Recent·Most cited

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

B. Boras, R. M. Jones, B. J. Anson, D. Arenson, L. Aschenbrenner, M. A. Bakowski, N. Beutler, J. Binder, E. Chen, H. Eng, J. Hammond, R. Hoffman, E. P. Kadar, R. Kania, E. Kimoto, , M. E. McGrath

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

bioRxiv · Sep 12, 2020 · PreprintPharmacology & Toxicology

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

M. de Vries, A. Mohamed, R. A. Prescott, A. Valero-Jimenez, L. Desvignes, R. O'Connor, C. Steppan, J. C. Devlin, E. Ivanova, A. Herrera, A. Schinlever, P. Loose, K. Ruggles, S. Koralov, A. Anderson, , M. Dittmann

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology