S. Alam

A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth

This paper develops a unified active fluid model to show that cytokinesis, cell crawling, and axonal outgrowth share common mechanisms of cytoskeletal flow, adhesion, and force generation.

Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

This paper develops Svg3, a cGAS-agonistic oligonucleotide, showing enhanced IFN-I responses and improved immunotherapy efficacy in preclinical models.

Peroxisomal compartmentalization of amino acid biosynthesis reactions imposes an upper limit on compartment size

The paper investigates how peroxisomal compartmentalization of amino acid biosynthesis reactions affects compartment size and redox balance in fission yeast.

Optimization of energy production and central carbon metabolism in a non-respiring eukaryote

This study compares metabolic strategies in two fission yeasts, showing how S. japonicus optimizes central carbon metabolism through glycerol-3-phosphate synthesis, a bifurcated TCA cycle, and the pentose phosphate pathway for higher ATP production.

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

CeTEAM evaluates drug-target interactions and phenotypic responses using biosensors, revealing how drug binding affects cellular activities and metabolism.

Tubular lysosome induction couples animal starvation to healthy aging

The paper shows that inducing tubular lysosomes through dietary restriction or mTOR inhibition links reduced food intake to lifespan extension in C. elegans.

Genotypic and phenotypic characterization of Streptococcus mutans isolated from dental caries

This study characterizes the genotypic and phenotypic diversity of Streptococcus mutans strains isolated from dental caries patients, revealing significant variability in traits like biofilm formation and acid production.

Phytochemical screening of Colocasia gigantea and Colocasia affinis (Family: Araceae) using 1H-NMR and 13C-NMR techniques

The paper identifies and characterizes seven phytochemical compounds from Colocasia affinis and Colocasia gigantea using 1H-NMR and 13C-NMR techniques.

Green Fabricated Zinc Oxide Nanoformulated Media Enhanced Callus Induction and Regeneration Dynamics of Panicum virgatum L.

This study uses zinc oxide nanoparticles to enhance callus induction and regeneration in Panicum virgatum, showing optimal results at 30 mg/L with 70-76% regeneration frequency.

CDK4 as a phytochemical based anticancer drug target

This study identifies mangiferin, a compound from mango trees, as a potential anticancer drug targeting CDK4, which is linked to cancer survival rates and expression patterns in GBM, LGG, and SARC.

The ARRIVE guidelines 2019: updated guidelines for reporting animal research

The paper updates the ARRIVE guidelines for reporting animal research, introducing an Essential 10 checklist and a Recommended Set to improve transparency and reproducibility.

Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019

This paper explains and elaborates on the revised ARRIVE guidelines for reporting animal research, providing rationale and examples to improve transparency and reproducibility.