Author

J. Brelstaff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. Y. Ng· 1 shared B. Li· 1 shared C. Bryant· 1 shared C. Summers· 1 shared D. Klenerman· 1 shared E. Fox· 1 shared M. Frontini· 1 shared P. Suresh· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperCell Biology

A. Y. Ng

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2 papers

Recent·Most cited

The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS

B. Li, P. Suresh, J. Brelstaff, S. Kedia, C. Bryant, D. Klenerman

This study shows that Aβ aggregates trigger TLR4 less efficiently than LPS due to slower Myddosome formation and longer lifetimes of larger Myddosomes.

bioRxiv · Sep 28, 2023Biophysics

Efficient methods for target gene manipulation in haematopoietic stem cell derived human neutrophils.

A. Y. Ng, E. Fox, J. Brelstaff, M. Frontini, C. Summers

The paper presents a method to genetically manipulate human neutrophils derived from haematopoietic progenitors, showing CD11b is not required for phagocytosis of opsonized bacteria.

bioRxiv · Jun 17, 2023 · PreprintCell Biology