Author

M. Frontini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

F. Burden· 2 shared A. Constantinescu-Bercu· 1 shared A. M. Dinan· 1 shared A. Mathur· 1 shared A. Y. Ng· 1 shared C. Kempster· 1 shared C. Summers· 1 shared E. Fox· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

F. Burden

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Author profile →

4 papers

Recent·Most cited

Efficient methods for target gene manipulation in haematopoietic stem cell derived human neutrophils.

A. Y. Ng, E. Fox, J. Brelstaff, M. Frontini, C. Summers

The paper presents a method to genetically manipulate human neutrophils derived from haematopoietic progenitors, showing CD11b is not required for phagocytosis of opsonized bacteria.

bioRxiv · Jun 17, 2023 · PreprintCell Biology

Epigenetic and transcriptional plasticity drive inflammation in Cystic Fibrosis

A. M. Dinan, O. Eneje, K. P. Brown, F. Burden, M. Morse, R. Prinjha, M. Frontini, R. A. Floto

The paper links acute pulmonary exacerbations in Cystic Fibrosis to immune signaling and epigenetic changes, showing antibiotic treatment reverses these effects.

bioRxiv · Oct 12, 2022 · PreprintImmunology

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

F. A. Choudry, F. Otzen Bagger, I. C. Macaulay, S. Farrow, F. Burden, C. Kempster, H. McKinney, L. R. Olsen, N. Huang, K. Downes, T. Voet, R. Uppal, J. Martin, A. Mathur, W. h. Ouwehand, , M. Frontini

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.

bioRxiv · Feb 20, 2020 · PreprintCell Biology

Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2

A. Constantinescu-Bercu, L. Grassi, M. Frontini, I. I. Salles-Crawley, K. J. Woollard, J. T. Crawley

The paper shows that activated platelet integrin IIbβ3 mediates flow-dependent neutrophil extracellular trap formation via SLC44A2, with a polymorphism in SLC44A2 protecting against venous thrombosis.

bioRxiv · Oct 25, 2019 · PreprintCell Biology