BioengineeringbioRxiv
CryoEM reveals unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
M. Kschonsak, C. C. Jao, C. P. Arthur…·J. C. Tellis
This study uses cryo-EM to reveal a new binding site for NaV1.7 inhibitors, enabling the design of hybrid inhibitors with improved selectivity and properties.
DOI 10.7554/elife.84151