Author

J. Case

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Sottoriva· 1 shared B. Werner· 1 shared C. P. Barnes· 1 shared D. Barker· 1 shared D. K. Phung· 1 shared D. Nichol· 1 shared D. P. Baquero· 1 shared D. Temko· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. Sottoriva

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Author profile →

2 papers

Recent·Most cited

Cbp1-Cren7 chromatinization of CRISPR arrays favours transcription from leader- over cryptic promoters

F. Blombach, M. Sykora, J. Case, X. Feng, D. P. Baquero, T. Fouqueau, D. K. Phung, D. Barker, M. Krupovic, Q. She, F. Werner

The paper shows that Cbp1-Cren7 chromatinization suppresses cryptic promoter activity and enhances transcription from leader promoters in CRISPR arrays.

bioRxiv · Mar 24, 2023 · PreprintMicrobiology

Measuring single cell divisions in human cancers from multi-region sequencing data

B. Werner, J. Case, M. J. Williams, K. Chkhaidze, D. Temko, J. Fernandez-Mateos, G. D. Cresswell, D. Nichol, W. Cross, I. Spiteri, W. Huang, I. Tomlinson, C. P. Barnes, T. A. Graham, A. Sottoriva

This study measures single-cell division rates and survival in human cancers using multi-region sequencing data, revealing per-cell mutation and survival rates across different cancer types and healthy tissues.

bioRxiv · Feb 25, 2019 · PreprintCancer Biology