Author

Q. She

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

Y. Shen· 5 shared Q. Huang· 4 shared X. Feng· 4 shared J. Ni· 3 shared Y. Chen· 3 shared Y. Yang· 3 shared M. Feng· 2 shared M. Krupovic· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersMicrobiology

Y. Shen

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system for Saccharolobus islandicus

P. Zhao, X. Bi, X. Wang, X. Feng, Y. Shen, G. Yuan, Q. She

The paper designs mutated pRN1 plasmid backbones to evade CRISPR immunity in Saccharolobus islandicus, enabling stable plasmid vectors and a dual plasmid system for genetic studies.

bioRxiv · Oct 26, 2023 · PreprintMicrobiology

The canonical single-stranded DNA binding protein SSB is not an essential replication protein but an RNA chaperon in the hyperthermophilic archaeon Saccharolobus islandicus REY15A

Y. Xiao, Z. Jiang, M. Zhang, X. Zhang, Q. Gan, Y. Yang, P. Wu, X. Feng, J. Ni, X. Dong, Q. She, Q. Huang, Y. Shen

This study shows that the canonical SSB in Saccharolobus islandicus REY15A is not essential for DNA replication but functions as an RNA chaperone, with conserved activities in related archaea.

bioRxiv · Jul 6, 2023 · PreprintMicrobiology

Cbp1-Cren7 chromatinization of CRISPR arrays favours transcription from leader- over cryptic promoters

F. Blombach, M. Sykora, J. Case, X. Feng, D. P. Baquero, T. Fouqueau, D. K. Phung, D. Barker, M. Krupovic, Q. She, F. Werner

The paper shows that Cbp1-Cren7 chromatinization suppresses cryptic promoter activity and enhances transcription from leader promoters in CRISPR arrays.

bioRxiv · Mar 24, 2023 · PreprintMicrobiology

Long-B prokaryotic Argonaute systems employ various effectors to confer immunity via abortive infection

X. Song, S. Lei, S. Liu, Y. Liu, P. Fu, Z. Zeng, K. Yang, Y. Chen, M. Li, Q. She, W. Han

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.

bioRxiv · Mar 9, 2023 · PreprintMicrobiology

Remodeling of a tripartite substrate-binding motif in the HD domain provides the mechanism for activation of CRISPR-Cas10 DNases

Z. Yu, F. Wang, Q. She

The paper investigates how the HD domain of LdCsm DNase is activated by remodeling a tripartite substrate-binding motif through RNA-induced structural changes.

bioRxiv · Nov 7, 2022 · PreprintMicrobiology

The archaeal KEOPS complex possesses a functional Gon7 homolog and has an essential function independent of cellular t6A modification level

P. Wu, Q. Gan, X. Zhang, Y. Yang, Y. Xiao, Q. She, J. Ni, Q. Huang, Y. Shen

This study identifies the archaeal KEOPS complex subunits and shows its essential function independent of t6A modification.

bioRxiv · Aug 26, 2022Microbiology

A novel RHH family transcription factor aCcr1 and its viral homologs dictate cell cycle progression in archaea

Y. Yang, J. Liu, X. Fu, F. Zhou, S. Zhang, X. Zhang, Q. Huang, M. Krupovic, Q. She, J. Ni, Y. Shen

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

bioRxiv · Jul 7, 2022Microbiology

A short prokaryotic argonaute cooperates with membrane effector to confer antiviral defense

Z. Zeng, Y. Chen, R. Pinilla-Redondo, S. A. Shah, F. Zhao, C. Wang, Z. Hu, C. Zhang, R. Whitaker, Q. She, W. Han

The paper identifies a short prokaryotic argonaute (pAgo) in Sulfolobus islandicus that, along with Aga1 and Aga2, provides antiviral defense through abortive infection.

bioRxiv · Dec 9, 2021 · PreprintMicrobiology

A well conserved archaeal B-family polymerase functions as a mismatch and lesion extender

X. Feng, B. Zhang, Z. Gao, R. Xu, X. Liu, S. Ishino, M. Feng, Y. Shen, Y. Ishino, Q. She

The paper characterizes Sulfolobus islandicus DNA polymerase 2 (Dpo2), showing it extends mismatches and lesions but lacks 3-5 exonuclease activity, suggesting a role in DNA repair.

bioRxiv · Sep 10, 2021 · PreprintMicrobiology

Structures of the Cmr-βComplex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

N. Sofos, M. Feng, S. Stella, T. Pape, A. Fuglsgang, J. Lin, Q. Huang, Y. Li, Q. She, G. Montoya

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.

bioRxiv · Jun 24, 2020Biochemistry

Negative interplay between biofilm formation and competence in the environmental strains of Bacillus subtilis

Q. She, E. Hunter, Y. Qin, S. Nicolau, E. A. Zalis, H. Wang, Y. Chen, Y. Chai

This study shows that robust biofilm formation in environmental Bacillus subtilis strains reduces competent cell rates through cross-pathway regulation between biofilm and competence systems.

bioRxiv · Jun 15, 2020Microbiology