Author

D. Barker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. A. A. Antwi· 1 shared A. D'Halluin· 1 shared A. Rodgers· 1 shared A. Tabib-Salazar· 1 shared B. Liu· 1 shared D. A. I. Mavridou· 1 shared D. Gonzalez· 1 shared D. K. Phung· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperMicrobiology

A. A. A. Antwi

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5 papers

Recent·Most cited

Cbp1-Cren7 chromatinization of CRISPR arrays favours transcription from leader- over cryptic promoters

F. Blombach, M. Sykora, J. Case, X. Feng, D. P. Baquero, T. Fouqueau, D. K. Phung, D. Barker, M. Krupovic, Q. She, F. Werner

The paper shows that Cbp1-Cren7 chromatinization suppresses cryptic promoter activity and enhances transcription from leader promoters in CRISPR arrays.

bioRxiv · Mar 24, 2023 · PreprintMicrobiology

Huntingtin turnover: Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550

Y. Lee, H. Kim, D. Barker, R. Vijayvargia, R. S. Atwal, H. Specht, H. Keshishian, S. A. Carr, R. Lee, S. Kwak, K.-g. Hyun, J. Loupe, M. E. MacDonald, J.-J. Song, I. Seong

The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.

bioRxiv · May 4, 2022 · PreprintBiochemistry

Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding

R. C. D. Furniss, N. Kaderabkova, D. Barker, P. Bernal, E. Maslova, A. A. A. Antwi, H. E. McNeil, H. L. Pugh, L. Dortet, J. M. A. Blair, G. Larrouy-Maumus, R. R. McCarthy, D. Gonzalez, D. A. I. Mavridou

This paper shows that disrupting disulfide bond formation in Gram-negative bacteria sensitizes them to antibiotics by impairing resistance proteins.

bioRxiv · Aug 27, 2021Microbiology

The Mycobacterium tuberculosis sRNA F6 modifies expression of essential chaperonins, GroEL2 and GroES

J. Houghton, A. Rodgers, G. Rose, A. D'Halluin, T. Kipkorir, D. Barker, S. Waddell, K. B. Arnvig

This study identifies the M. tuberculosis sRNA F6 as a regulator of chaperonin expression under starvation conditions, suggesting a role in long-term survival.

bioRxiv · Jul 15, 2020Microbiology

A T7 phage factor required for managing RpoS in Escherichia coli

A. Tabib-Salazar, B. Liu, D. Barker, L. Burchell, U. Qimron, S. Matthews, R. Wigneshweraraj

This paper identifies Gp5.7 as a T7 phage protein that inhibits EσS in stationary phase E. coli, enabling T7 development in both exponential and stationary growth phases.

bioRxiv · Apr 4, 2018Microbiology